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With moods, it can go both ways. There is medication that changes the chemicals in the brain that control moody. So, if someone takes anti-depression medication and it actually works, then the person shouldn't feel depressed. However, you can override the medications at certain times if something wins out. Fight or flight factors, when fear starts to pump out adrenaline. That overrides medication.

I don't know about the second. Some people are particularly frightened of certain things, and others aren't. A person may have no interaction with a fear, yet they have that fear.

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